Diapedesis

Diapedesis is the migration of leukocytes through the walls of blood vessels and their entry into tissues, which is an important stage of the inflammatory response. This response begins after injury or infection and its purpose is to destroy pathogens and protect the body from their effects.

Diapedesis occurs due to the movement of leukocytes, which migrate through the endothelial cells of the vessel wall and penetrate the tissue. This movement is regulated by various factors such as cytokines, hormones and other inflammatory mediators.

In tissues, leukocytes undergo activation and begin to perform their functions, such as phagocytosis, production of cytokines and other active substances. They can also interact with other cells and tissues to increase inflammation and protect the body from infection.

However, diapedesis can be harmful if it is not stopped promptly, as it can lead to tissue damage and complications. Therefore, it is important to control inflammation and manage its development to avoid unwanted consequences.

Diapedesis is the migration of blood cells through the walls of blood vessels into nearby tissues. This process is very important for the tissue response to various injuries and damage.

Diapedesis plays a key role in the process of inflammation, which is the body's defense response to infection or injury. When injury occurs in the body, blood vessels dilate, allowing blood cells to flow into surrounding tissue where they can begin the repair process.

In tissues that receive a large number of diapedesized cells, active cell division and growth occurs, which helps restore damaged tissue and eliminate the cause of injury.

In addition, diapedesis can be used to diagnose various diseases. For example, in some blood diseases, such as leukemia, diapedesic cells may be found in the body's tissues, which may indicate the presence of the disease.

Thus, diapedesis is an important process that helps the body recover from injury and damage, and can also be used to diagnose various blood diseases.

**Diapedesis** - migration of leukocytes into tissues during inflammatory processes. The mechanism of diapedesis is that the liquid, which contains microorganisms or other aggressive agents, easily passes through the capillary wall, since it is unstable and can penetrate outward. This occurs under the influence of pressure from microorganisms or other factors. After some time, when inflammation develops, leukocytes join this process. Moving behind the flow of liquid from the vessel, they penetrate the capillary membrane. Then their membranes stick together and their movement becomes slower. This condition is called transitional and lasts about 3-5 days. After this period, leukocytes acquire a negative charge. At the same time, they begin to fight inflammation using the lysosome. As immune cells migrate in response to microbial or other aggression, biofilm formation occurs. These are protective structures in the environment, consisting of cell walls of microorganisms, tissue debris, polymers, etc. Thus, diapedesis of leukocytes leads to their binding to biofilm components and the formation of protective structures. These structures do not allow harmful agents to develop at the site of inflammation, so it gradually fades away.