Diclofenac-Ratiopharm

Country of origin - Germany, Ratiopharm GmbH, produced by Merkle GmbH Germany
Pharm-Group - Anti-inflammatory drugs - phenylacetic acid derivatives

Manufacturers - Ratiopharm GmbH (Germany), Ratiopharm GmbH, produced by Merkle GmbH (Germany)
International name - Diclofenac
Synonyms - Allovoran, Almiral, Apo-Diklo, Betaren, Bioran, Bioran Rapid, Blesin, Veral, Vernak, Voltaren, Voltaren Akti, Voltaren Rapid, Voltaren SR, Votrex, Dignofenac 100, Dignofenac 50, Diklak, Diklo, Diklo-F, Diklobene, Dikloberl 100, Dikloberl 25, Diklober

Dosage forms - film-coated tablets 25 mg, film-coated tablets 50 mg, retard capsules 100 mg, suppositories 50 mg, suppositories 100 mg, enteric film-coated tablets 50 mg
Composition - Active substance - diclofenac sodium.

Indications for use - Inflammatory diseases of the joints (rheumatoid arthritis, rheumatism, ankylosing spondylitis, chronic gouty arthritis), degenerative diseases (deforming osteoarthritis, osteochondrosis), lumbago, sciatica, neuralgia, myalgia, diseases of extra-articular tissues (tenosynovitis, bursitis, rheumatic soft tissue damage ), post-traumatic pain syndromes accompanied by inflammation, postoperative pain, acute attack of gout, primary dysmenorrhea, adnexitis, migraine attacks, renal and hepatic colic, infections of the ENT organs, residual effects of pneumonia. Locally - injuries of tendons, ligaments, muscles and joints, localized forms of soft tissue rheumatism. In ophthalmology - non-infectious conjunctivitis, post-traumatic inflammation after penetrating and non-penetrating wounds of the eyeball, pain syndrome when using an excimer laser, during surgery for removal and implantation of the lens (pre- and postoperative prevention of miosis, cystoid edema of the optic nerve).

Contraindications - Hypersensitivity, hematopoietic disorders, gastric and duodenal ulcers, aspirin-induced bronchial asthma, children (up to 6 years), last trimester of pregnancy.

Side effects - From the gastrointestinal tract: gastralgia, nausea, vomiting, diarrhea, stomach cramps, dyspepsia, flatulence, anorexia. From the side of the central nervous system: headache, dizziness, fatigue. From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia. There is a burning sensation at the site of intramuscular injection. When using suppositories - local irritation. Skin: skin rashes, urticaria, itching, burning. With long-term use and/or application to large surfaces, systemic side effects due to resorptive effects occur. Immediately after instillation into the eyes - a passing burning sensation and/or blurred vision.

Interaction - Increases the blood concentration of lithium, digoxin, indirect anticoagulants, oral antidiabetic drugs (both hypo- and hyperglycemia are possible), quinolone derivatives. Increases the toxicity of methotrexate, cyclosporine, the likelihood of developing side effects of glucocorticoids (gastrointestinal bleeding), the risk of hyperkalemia against the background of potassium-sparing diuretics, reduces the effect of diuretics. Plasma concentrations decrease with the use of acetylsalicylic acid.

Overdose - When taken orally: Symptoms: dizziness, headaches, hyperventilation, clouding of consciousness, in children - myoclonic convulsions, disorders of the gastrointestinal tract, liver and kidney functions. Treatment: symptomatic therapy.

Special instructions - In order to quickly achieve the desired effect, oral forms of diclofenac are taken 30 minutes before meals. After removing contact lenses, instillation is performed after 5 minutes. Preparations for topical use are applied only to intact areas of the skin. For a long time