Dipiroxime

Dipiroxime: a cholinesterase reactivator for the treatment of poisonings

Dipiroxime, also known as trimedoxine bromide, is a medicine used to treat poisoning caused by cholinesterase inhibitors, such as some pesticides and nerve poisons. Dipiroxime belongs to the group of cholinesterase reactivators, which restore cholinesterase activity, accelerating the breakdown of acetylcholine and restoring the normal functioning of the nervous system.

Dipiroxime was developed in 1961 and has since been successfully used to treat poisoning caused by cholinesterase inhibitors. It is highly effective and safe when used correctly, making it an indispensable tool in the treatment of such poisonings.

To treat poisoning, dipyroxime is administered intravenously at a dose of 10 to 20 mg/kg for an adult patient, depending on the severity of the poisoning. If necessary, the dose can be repeated after 1-2 hours. Treatment with dipyroxime should begin as soon as possible after poisoning to prevent the development of serious complications.

Although highly effective and safe, dipyroxime may cause some side effects such as nausea, vomiting, headache and fatigue. However, these effects usually resolve quickly and do not require interruption of treatment.

In conclusion, dipyroxime is an important drug for the treatment of poisoning caused by cholinesterase inhibitors. It is highly effective and safe, which makes it an indispensable tool in the treatment of such poisonings. However, before using dipyroxime, you should consult your doctor and strictly follow the dosage and use recommendations to avoid possible side effects.