Dysostosis bone disease is a systemic metabolic pathology, a pathology of connective tissue, which is characterized by progressive dystrophic degeneration of bone and cartilaginous tissues. It develops under various exogenous and endogenous influences on the body. Exogenous factors depend on the place of permanent or temporary stay of the patient - place of residence or work in an environmentally unfavorable area, under the influence of harmful production factors or frequent infectious diseases, heavy physical activity. Endogenous causes of development are observed after somatic pathologies, in patients with disorders of the central nervous system and endocrine system. Primary forms of dysostosis are not associated with any chemical or infectious agents. The disease develops against the background of previous congenital abnormalities of connective tissue, as well as due to exposure to physical factors. Secondary forms of pathology include acquired diseases after disruption of the normal trophism of connective tissue in the area of the heart or brain structures.