Erythroblast

An erythroblast is an immature precursor cell to erythrocytes (red blood cells). Erythroblasts are formed in the bone marrow from hematopoietic stem cells during the process of erythropoiesis.

As they mature, erythroblasts decrease in size, lose their nucleus, and accumulate hemoglobin. There are several stages of erythroblast maturation: pronormoblast, basophilic normoblast, polychromatophilic normoblast and orthochromatophilic normoblast. Fully mature erythroblasts turn into reticulocytes, which leave the bone marrow and circulate in the blood, where they mature into mature red blood cells.

Thus, erythroblasts play a key role in the process of hematopoiesis, ensuring the formation of red blood cells and maintaining normal hemoglobin levels in the blood. Impairments in the maturation and proliferation of erythroblasts can lead to the development of anemia.

Erythroblastic maturation of the bone marrow is a process of “rebooting” hematopoiesis, which results in the formation of all mature red and white blood cells from precursors received from lymph nodes and organs of myeloid origin.

Erythroblasts - red germ cells, hematopoiesis