Erythroblastic Reaction

Erythroblasts are nucleated cells that are formed in the bone marrow and serve to produce red blood cells. The erythroblastic reaction is a temporary increase in the number of erythroblasts in the bone marrow without changing their quality. This phenomenon can be observed with some blood diseases, such as hemolytic anemia, as well as with blood loss.

The erythroblastic reaction occurs due to increased production of erythropoietin, a hormone that stimulates the formation of new red blood cells. At the same time, the quantity of erythroblates increases, but their quality remains unchanged.

One example of an erythroblastic reaction is hemolytic anemia, which occurs when red blood cells are destroyed due to various factors. This causes the bone marrow to produce more red blood cells to compensate for the loss of red blood cells.

Another example of an erythroblastic reaction is blood loss. When blood is lost, the bone marrow responds by increasing the production of erythroblasts. This allows the body to quickly restore the level of red blood cells and avoid anemia.

In general, the erythroblastic reaction is an important mechanism for regulating the number of red blood cells in the blood. It allows the body to adapt to various conditions and maintain the normal functioning of all organs and systems.

The erythroblastic reaction is a temporary increase in the number of erythroids that also have the characteristics of nucleated cells - proerythroblasts. This increase is accompanied by increased division of proeryroblasts, thereby increasing the number of nuclei and hemoglobin in the cells. An increase in their number is called hyperplasia, and an increase in their ability to divide is characterized as proliferation.

Erythroblastic reaction

**Erythroblastic reaction (erythroblastosis, alloreism)** is a change in a blood cell without loss of its genetic information. In this case, the cell changes its external and some internal characteristics, as well as the structure of the nucleus. Erythropoietic cells (progenitor red blood cells or red blood cells) change, but do not die. This phenomenon is observed not only in hemolytic anemia, but also in children with aplastic anemia or after removal of the spleen. How does the reaction occur in the body and the pathology of red blood cells change?

Analysis of the state of the hematopoietic organ system

The reaction occurs due to the initiation of cell division, but a new red blood cell is not born until the maturation process is completed. During the erythroblastic reaction, the number of red blood cells first increases. After the migration of maturing cells in adults begins to end, and division continues for several days, the volume of the internal sector begins to grow - the replacement of old cells with new cells to maintain the norm.

As the body receives nitrogen and microelements for maturation, they begin to use precursor molecules, that is, synthesize the necessary protein from amino acids - the main part of the process begins. Several of the new red blood cell cells continue to divide up to a certain time - in approximately 90% of adolescents, up to 90% of cells mature in 2 days; in adults, on average, 35% per day.

Then the area of ​​the endoplasmic reticulum, which is formed during cell development, slowly decreases, and hemoglobin stops synthesis even before maturation - there are only single mature forms. The number of maturing red blood cells gradually decreases. Because of this, when the number of new blood cells maturing stops, the old ones remain at a level that does not coincide with the norm. The concentration of erythrocytes is still high, which means that the patient would feel euphoria and a surge of strength. But immature cells can mix with other positive ones, which changes the signs of the disease.

In such cases, you need to know that cell formation will not disappear on its own - you can monitor it through regular blood tests. What is a mild erythrocyte reaction? This is what we're talking about