Fibrinogenolysis

Fibrinogenolysis is the process of breaking down fibrinogen, a blood plasma protein that is involved in blood clotting.

Fibrinogen is synthesized in the liver and circulates in the blood. When blood vessels are damaged, it turns into fibrin threads, which form a clot that stops bleeding.

The breakdown of fibrinogen is catalyzed by the enzyme fibrinolysin, which is produced in the kidneys, liver and spleen. Fibrinolysin breaks down fibrinogen into degradation products - fibrinopeptides.

Fibrinogenolysis plays an important role in maintaining homeostasis by preventing excessive blood clotting. An imbalance between coagulation and fibrinolysis can lead to thrombosis or bleeding. Control of fibrinogen levels and fibrinolysin activity is necessary for normal hemostasis.