Fibrin-derived substance (FFS) is a non-cellular material that is formed as a result of blood clotting. VWF is made up of fibrin, soluble fibrinopeptides and other proteins such as clotting factors, as well as blood cells that have been destroyed during the clotting process.
VWF plays an important role in hemostasis, that is, in stopping bleeding. When a blood vessel is damaged, platelets and other clotting factors are activated and begin to form fibrin, which then thickens and seals the wound.
However, VWF can also cause health problems. For example, in some blood diseases, such as hemophilia, VWF is produced in excess and can cause bleeding and other complications. Also, VWF can accumulate in tissues and organs, causing damage and inflammation.
Various methods are used to treat these problems, including blood transfusions, drugs that block the formation of VWF, and surgical methods to remove excess VWF. Overall, understanding the role of VWF in blood coagulation and its impact on health is important for the development of new treatments and disease prevention.