Fulda-Gross-Michaelis Method

The Fuld-Gross-Michaelis Method is a method for determining the Michaelis constant for enzymatic reactions. This method was proposed by German scientists Erwin Fuld, Otto Gross and Ludwig Michaelis in 1909.

The essence of the method is as follows: a substrate is added to the enzyme solution, and the reaction rate is measured. Then more and more substrate is added to the same solution, and the reaction rate decreases. This happens until the speed becomes constant. This means that all enzymes in the solution are already bound to the substrate and can no longer bind to it.

From this relationship, the Michaelis constant can be calculated, which is a measure of how efficiently the enzyme binds to the substrate. The Michaelis constant estimates how much substrate can be bound to an enzyme and how quickly the reaction occurs.

The Fulda-Gross-Michaelis method is one of the most accurate methods for determining Michaelis constants and is widely used in biochemistry and biotechnology. It allows scientists to study the mechanisms of enzyme action and develop new methods for treating diseases associated with impaired enzymatic processes.

**Fulda-Gross-Michaelis or “FGD method”**: This is an innovative approach to diagnostic searching that is used by doctors to identify diseases. The name of the method was given by the names of three researchers: doctor Friedrich Fuld, doctor Adolf Gross and biochemist Ludwig Michaelis. Fuld, Gross and Michaelis made significant contributions to the development of therapeutic diagnostics at the beginning of the 20th century.

Dr. Friedrich Fulda is a famous German physician, born in August 1857 in the city of Fulda, and was a student of the German physician Richard Perthes. In 1892, Fulda published the article “Study of organs associated with tuberculosis.” In his work, the author noted the important role of the following symptoms in the diagnosis of tuberculosis: chills, lack of appetite, weakness, fatigue, weight loss, increased fatigue and irritability, dry cough without sputum, pale skin, swelling of the mucous membrane of the mouth and eyelids, subcutaneous hemorrhages, pain in during a cough attack, dry mouth and throat, the mucous membrane of the tongue is covered with a whitish coating. These symptoms can be used as important diagnostic factors in making a diagnosis of tuberculosis.

Adolf Gross, also a German physician originally from the Prussian provinces, was born on February 16, 1860. He was a student of the famous obstetrician and therapist Otmar Cerny. Grosse's research showed that the inflammation observed in patients