Haloperidol Decanoate

Haloperidol decanoate

Country of origin - Hungary
Pharm-Group - Neuroleptics - butyrophenone derivatives

Manufacturers - Gedeon Richter A.O. (Hungary)
International name - Haloperidol
Synonyms - Apo-Haloperidol, Haloper, Haloperidol, Haloperidol-Acri, Haloperidol-Ratiopharm, Haloperidol-Ferein, Haloperidol-Ferein, Senorm, Trankodol-5
Dosage forms - solution for injection, oily 50 mg, solution for injection, oily 50 mg/ml
Composition - Active substance - Haloperidol

Indications for use - Psychomotor agitation of various origins (mania, dementia, mental retardation, psychopathy, acute and chronic schizophrenia, chronic alcoholism), delusions and hallucinations, paranoid states, acute psychosis, chorea, incessant vomiting, psychomatic agitation, behavioral disorders in the elderly and children age, stuttering, hiccups.

Contraindications - Hypersensitivity, including to sesame oil, diseases of the central nervous system accompanied by pyramidal and extrapyramidal symptoms, depression, coma, pregnancy, lactation, age under 3 years.

Side effects - Headache, insomnia or drowsiness, agitation, restlessness, anxiety, fears, euphoria or depression, lethargy, epileptic attacks, hallucinations. With longer use - extrapyramidal disorders, tardive dyskinesia, neuroleptic malignant syndrome, accompanied by hyperthermia, muscle rigidity, loss of consciousness. When used in high doses - hyposalivation, nausea, vomiting, constipation or diarrhea, arterial hypotension, tachycardia, arrhythmia, ECG changes, sometimes - liver dysfunction, acne-like skin changes, rarely - visual impairment, laryngospasm, bronchospasm, pain in the mammary glands, gynecomastia, menstrual irregularities, impotence, increased libido, urinary retention, sweating, alopecia, temporary leukopenia, erythropenia, hyperprolactinemia, hyper- and hypoglycemia, hyponatremia, photosensitivity.

Interaction - Enhances the effect of antihypertensive drugs, opioid analgesics, antidepressants, barbiturates, alcohol, weakens the effect of indirect anticoagulants. Inhibits the metabolism of tricyclic antidepressants and increases toxicity. With long-term use of carbamazepine, plasma levels of haloperidol fall. In combination with lithium, it can cause an encephalopathy-like syndrome.

Overdose - Symptoms: severe extrapyramidal disorders, arterial hypotension, drowsiness, lethargy. In severe cases - coma, respiratory depression, shock. Treatment: there is no specific antidote. Gastric lavage is possible, followed by

Special instructions - Prescribe with caution to patients suffering from cardiovascular diseases with symptoms of decompensation, conduction disorders of the heart muscle and kidney function. With the development of tardive dyskinesia, a gradual dose reduction is recommended, until discontinuation. During therapy, patients must refrain from engaging in potentially hazardous activities that require increased attention and rapid mental and motor reactions.

Literature:

1. Encyclopedia of drugs 2002
2. Russian edition USP DI issue No.1.
3. Directory "Medicines" Mashkovsky M.D. 13th edition.