Hyperkeratosis perungualis is a nail disease that can occur in people of all ages. However, it is more common in men and women over 50 years of age. This is not an infectious disease, but a chronic lesion of the nail plate. It occurs in 15% of patients complaining of nails and is accompanied by a change in their color, thickening and pain. Causes of hyperkeratosis of the nail plate There are many causes of this disease, most of them depend on a person’s lifestyle, but a hereditary predisposition is also possible. Here are several causes of this condition: * Diabetes mellitus * Fungus