Hypercreatinemia

Hypercreatinemia: Understanding and Managing Elevated Creatinine Levels

Hypercreatinemia, also known as hypercreatininemia, is a medical condition characterized by elevated levels of creatinine in a patient's blood. Creatinine is a metabolic product of creatine, a substance that plays an important role in muscle energy metabolism. Creatinine is usually excreted from the body through the kidneys. However, with impaired renal function or other factors, the creatinine level may increase, indicating the presence of hypercreatinemia.

The causes of hypercreatinemia can be varied. One of the most common causes is chronic kidney failure, in which the kidneys are unable to effectively filter creatinine and remove it from the body. Other possible causes include acute renal failure, dehydration, myopathies (muscle diseases), muscle trauma, muscle breakdown syndrome, and certain medications.

Elevated blood creatinine levels can be associated with various symptoms and complications. Patients with hypercreatinemia may experience fatigue, weakness, decreased appetite, nausea, and kidney pain. In more severe cases, it can progress to acute or chronic kidney failure, which requires medical intervention and treatment.

The diagnosis of hypercreatinemia is usually based on testing the level of creatinine in the blood. Your doctor may also order additional tests to determine the cause of your elevated creatinine levels and to evaluate your kidney function. It is important to note that hypercreatinemia may be a sign of an underlying disease, so additional examinations must be carried out to identify possible pathologies.

Treatment of hypercreatinemia is aimed primarily at eliminating the underlying disease or factor causing elevated creatinine levels. In cases of chronic renal failure, dialysis or a kidney transplant may be required. Monitoring creatinine levels and regular monitoring are important aspects of managing hypercreatinemia.

Prevention of hypercreatinemia includes maintaining a healthy lifestyle, regular exercise, and avoiding risk factors such as excess alcohol consumption and managing underlying medical conditions that can lead to elevated creatinine levels.

In conclusion, hypercreatinemia is a condition characterized by elevated levels of creatinine in the blood. It can result from a variety of causes, including kidney dysfunction, muscle disease, and other factors. The diagnosis of hypercreatinemia is based on analysis of creatinine levels, and treatment is aimed at eliminating the underlying disease. Regular monitoring and monitoring of creatinine levels plays an important role in managing this condition. If you suspect hypercreatinemia, it is important to see your doctor to get an accurate diagnosis and determine the best treatment plan.

Hypercreatininemia – clinical and diagnostic aspects.

hypercreatinemia. It occurs with excessive formation and release of creatinine, which may be a consequence of increased catabolism of muscle tissue or kidney pathology. Its nonspecific signs include weight loss, lethargy, weakness, sluggish pupil reaction, muscle weakness, drowsiness, dry skin and mucous membranes, brittle nails, cold extremities, decreased appetite, increased body temperature, etc. A person suffering from this pathology needs careful diagnosis and specialized treatment, since this condition can cause the development of heart failure, impaired liver and kidney function, as well as other severe pathologies [7].

The causes of excess creatinine depend on the age of the patient. If a similar condition develops in children at an early age, the cause is a deficiency or absence of an enzyme in the kidneys that transforms creatine into creatidine phosphate. A common cause of excess synthesis of this substance in athletes is a violation of exercise technique and diet, non-compliance with which leads to excessive synthesis of creatine in the muscles and accelerated its removal from the body through the kidneys, due to which creatinine rises in the blood [6].

Hypercreatininemia occurs equally in men and women, regardless of their age. The exception is men of a certain age after playing sports. Factors influencing the development of excess of the substance in question in the body can be fasting, physical inactivity, obesity, etc. [2]. Common factors include the use of anabolic steroids in sports, abuse of salt, protein foods, and heavy loads on the heart and kidneys [8].

Diagnosis includes a general blood test, which reveals anemia, leukocytosis, thrombocytopenia, an increase in the concentration of creatikine in the blood with signs of hyporeflexia and hypotension, and impaired filtration and secretory function of the kidneys [4]. Patients are prescribed an examination to identify cardiovascular complications: blood pressure measurement, electrocardiogram, echocardiography and other heart studies, biochemical tests of urine and blood [9].

Of all the possible tests, it is most advisable to determine the level of BUN and creatinine. When conducting research, patients with hypercreatinimia often have to deal with a significant deficiency of microelements in the body (iron, magnesium, potassium, sodium), disturbances in electrolyte metabolism (sodium and potassium, magnesium and calcium, chlorides and bicarbonates). High levels of serum albumin, hematocrit, high platelets, low eosinophils, basophils, and neutrophils are also detected [5].

Treatment of patients with hypercreatinemia should be started as early as possible and must be carried out in specialized institutions. Lifestyle adjustments include a more thorough analysis of nutrition in terms of protein content and limitation of physical activity [5]. To achieve this goal, anabolic steroids are prescribed - methandienone, stanozolol. Steroids promote vasodilation and increase blood pressure [5]. Therapy may also include administration of alpha-ad