Gistalong

Manufacturer country

India

Pharm Group

H1-histamine receptor blockers

Manufacturers

Dr. Reddy's Laboratories Ltd (India)

International name

Astemizole

Synonyms

Astelong, Astemizole, Astemisan, Gismanal, Histazol, Mibiron, Stelert, Stemiz

Dosage forms

tablets 5mg, tablets 10mg

Compound

The active ingredient is astemizole.

Indications for use

Allergic rhinitis, allergic conjunctivitis, allergic skin reactions (chronic idiopathic urticaria, etc.), itching, angioedema (treatment and prevention), bronchial asthma (auxiliary therapy).

Contraindications

Hypersensitivity, pregnancy, breastfeeding, early childhood (up to 2 years). Restrictions on use: prolongation of the QT interval on the ECG, hypokalemia, severe liver dysfunction.

Side effect

From the nervous system and sensory organs: weakness, headache, drowsiness, in some cases - dizziness, nervousness, mood disorders, insomnia, nightmares, paresthesia, convulsions, rarely - depression, conjunctivitis. From the cardiovascular system: hypotension, palpitations, at high doses - ventricular arrhythmias, hematopoietic disorders (fatigue or weakness, sore throat, fever, bleeding or hemorrhage). From the gastrointestinal tract: dry mouth, increased appetite, nausea, abdominal pain, diarrhea, rarely - increased activity of liver transaminases, hepatitis. Allergic reactions: rarely - rash, itching, angioedema, bronchospasm, anaphylactoid reactions. Others: photosensitivity, weight gain, myalgia, arthralgia, rarely - pharyngitis.

Interaction

Imidazole antifungals (ketoconazole, intraconazole, miconazole, etc.), macrolides (erythromycin, clarithromycin, troleandomycin), metronidazole, quinine, mibefradil reduce the rate of biotransformation. It is not recommended to combine with HIV protease inhibitors and serotonin reuptake inhibitors. Drugs that prolong the QT interval (antiarrhythmic drugs, terfenadine, tricyclic antidepressants, phenothiazines, calcium channel blockers, etc.) potentiate cardiotoxicity. May mask the ototoxic effects of other drugs. Increases the side effects of photosensitizing agents.

Overdose

Symptoms: ventricular arrhythmias, syncope, convulsions, cardiac or respiratory arrest. Treatment: induction of vomiting, gastric lavage, taking activated charcoal, saline laxatives; ECG monitoring, symptomatic and supportive therapy, if necessary - in

special instructions

It is not recommended to take grapefruit juice at the same time (inhibits metabolism and increases concentration in the blood). Use caution in patients with kidney disease, impaired electrolyte metabolism, and receiving non-potassium-sparing diuretics. Patients with lower respiratory tract diseases should be warned about the potential anticholinergic effects. Use with caution to treat patients whose work requires increased attention and speed of physical reactions. It is recommended to discontinue use at least 4 weeks before performing a skin test for allergens.

Literature

Encyclopedia of drugs 2004.