Histamine Test 2

Histamine test 2 is a method for diagnosing pheochromocytomas, based on an increase in blood pressure after the administration of histamine. This method was developed in the 1970s and has since been one of the most accurate ways to diagnose pheochromocytoma.

The essence of the method is that the patient is injected intravenously with histamine, which causes a sharp rise in blood pressure. If a patient has pheochromocytoma, the blood pressure may increase by 50% or more. In addition, with pheochromocytoma, tachycardia is observed, which can also be detected during a histamine test.

The histamine test 2 uses a special needle to inject histamine and a blood pressure monitor that records changes in blood pressure within a few minutes of the injection.

The histamine test method 2 is the gold standard for diagnosing pheochromocytoma and allows you to detect the tumor at an early stage, when it does not yet manifest itself clinically. However, like any other diagnostic method, the histamine test has its limitations and can give false positive results. Therefore, additional tests such as computed tomography or magnetic resonance imaging must be performed to confirm the diagnosis of pheochromocytoma.

The histamine test is an important method for diagnosing pheochromocytoma, which helps to identify the tumor in the early stages and prevent the development of serious complications.

Histamine test II (bupivacaine test, Lagrange test) for the diagnosis of pheochromacytoma using injection intravenous (IV) bupivacaine (50 mg at a rate of 2.5 ml per minute) The test is carried out after determining the level of blood catecholamines (metanephrine and normetanephrine). Rina). Normally, parasympathetic influences should not reduce the severity of the effect of a histamine on the rise in blood pressure. The study is contraindicated within 40 days after surgery to remove pheochromacytoma tumors. Observe the patient without prescribing antihistamines for three days.