Glybutide

Glybutide: description, properties, application and side effects

Glybutide is an antidiabetic drug used to treat type 2 diabetes mellitus in adults. It belongs to the group of biguanides and is produced by a Russian manufacturer - the Tyumen Chemical and Pharmaceutical Plant.

The active ingredient of the drug is buformin. It reduces blood glucose levels by increasing tissue sensitivity to insulin. Glybutide can also be used in combination with insulin to treat insulin resistance.

Indications for the use of glybutide include type 2 diabetes mellitus in adults, including mild forms, primary and secondary resistance to sulfonylureas, and obesity.

Contraindications to the use of glibutide include hypersensitivity to the drug, coma, acidosis, albuminuria due to diabetic nephropathy, ketonuria, liver and kidney damage, pancreatitis, severe diseases of the cardiovascular and respiratory system, anemia, infectious diseases, fever, gangrene of the extremities, chronic alcoholism , pregnancy and breastfeeding.

Side effects of glybutide may include loss of appetite, nausea, vomiting, metallic taste, epigastric pain, and frequent bowel movements. Other possible side effects include weakness, weight loss, ketosis with decreased reserve alkalinity of the blood, acidosis and rarely allergic reactions (skin rashes, redness of the skin, itching).

Glybutide may interact with other drugs such as phenothiazine derivatives (including aminazine), corticosteroids, thyroid-stimulating hormones, estrogens, diuretics, MAO inhibitors, sulfonylureas and salicylates. It also enhances and prolongs the effects of exogenous insulin.

In case of an overdose of glybutide, symptoms of hypoglycemic coma may occur. Treatment includes immediate consumption of sugar, sweet hot tea, fruit juice, corn syrup, or honey. In case of severe overdose, administration of a 50% glucose solution may be required.

When prescribing glybutide, it is necessary to constantly monitor blood glucose levels, especially in patients with impaired renal and hepatic function. It is also necessary to constantly monitor kidney and liver function, the level of electrolytes in the blood and the acid-base status.

In general, glybutide is an effective drug for the treatment of type 2 diabetes, but its use should be limited only in accordance with the instructions and under the supervision of a physician. It is important to remember that self-medication can be hazardous to health. If you have symptoms of diabetes, consult your doctor for advice and proper treatment.