Glyzide: an effective antidiabetic agent
Glizide is a sulfonylurea antidiabetic drug used to treat type 2 diabetes mellitus. The active substance of the drug is gliclazide. Glizide is produced in India by Panacea Biotek and has the international name Gliclazide. The drug is available in the form of 80 mg tablets.
Indications for use
Glyzide is used for the treatment of type 2 diabetes mellitus in monotherapy or in combination with insulin or other oral hypoglycemic drugs. Type 2 diabetes is a disease in which blood sugar levels are elevated due to the body's ineffective use of insulin.
Contraindications
The drug is contraindicated in case of hypersensitivity to gliclazide, type 1 diabetes mellitus (including juvenile), ketoacidosis, diabetic (with ketoacidosis) and hyperosmolar coma, extensive injuries and burns, liver failure and severe forms of renal failure, hypo- and hyperthyroidism, pregnancy and lactation chest.
Side effects
From the gastrointestinal tract: very rarely - dyspeptic symptoms (nausea, vomiting, abdominal pain), jaundice. From the cardiovascular system and blood: reversible cytopenia, eosinophilia, anemia. From the skin: allergic skin reactions, photosensitivity. Metabolism: hypoglycemia. From the nervous system and sensory organs: weakness, headache, dizziness, changes in taste.
Interaction
Glyzide enhances the effect of ACE inhibitors, anabolic steroids, beta-blockers, fibrates, biguanides, chloramphenicol, cimetidine, coumarins, fenfluramine, fluoxetine, salicylates, guanethidine, MAO inhibitors, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamides, tetracycline inov. Barbiturates, chlorpromazine, glucocorticoids, sympathomimetics, glucagon, saluretics, rifampicin, thyroid hormones, lithium salts, high doses of nicotinic acid, oral contraceptives and estrogens, as well as alcohol may weaken the effect of glizide.
Dosage and method of administration
The dosage of gliside should be individual and determined depending on the level of glycemia. The usual starting dose is 40-80 mg once daily before meals. The maximum daily dose is 320 mg. If there is insufficient effectiveness, the dose can be increased to 160 mg or another drug for the treatment of diabetes can be added.
In conclusion, Glyzide is an effective antidiabetic agent that is used to treat type 2 diabetes mellitus. However, before