Griesinger's sign is a pathognomonic symptom of active tuberculosis, detected on radiographs and tomograms with direct projection (including oblique projections). It was first mentioned by the German physician Theodor Griesinger in 1886. It is considered a good indicator of the phase of the process and histological changes in the lung tissue. Used for monitoring and management of patients. The term “Griesinger's sign” ceased to be used when aspiration biopsy began to be used instead of contrast pleural puncture in the 50s of the 20th century.