Guaninde deaminase

Guanine deaminases are lidases in chimeric DNA that destroy its mutagenicity.

Guanine-C thymidine (GUA)-containing DNA fragments are the basis of recurrent bladder cancer. Bladder cancer is a heterogeneous disease that develops from the epithelium. The cell cycle transformation mechanism of degenerated epithelial cells determines the aggressive expression of guanosine 5'-deaminase (GDA). The loss of any of the two proteins GDA or GT1 is an integral feature of morphologically verified bladder cancer (pTNM stage pN+). GDA-catalyzed loss of ribo-2,