Khanganutsiu-Dichera-Paula-Bunnellia Reaction

The Hanganutsiu Daiher Paul Bunnell reaction (HDA PB reaction) is one of the methods for determining the activity of serum antibodies. It was developed by the Romanian immunologist M. Hanganutiu, the German doctor N. Deicher, and the American doctors J.R. Paul and W.W. Bunnell in the 20th century.

To carry out the reaction, the patient's blood serum and antigens are used, which cause the formation of antibodies. Then a solution containing sheep red blood cells is added and the amount of antibodies produced is measured. The result of the reaction is expressed as the number of antibodies per 1 ml of serum.

This reaction is used to diagnose various diseases, such as tuberculosis, syphilis, malaria and others. It can also be used to determine the effectiveness of treatment.

The Hanganutsiu Daiher Paul Bunnel reaction has high sensitivity and specificity, which makes it one of the most accurate methods for determining antibody activity. However, to obtain reliable results, it is necessary to correctly carry out all stages of the reaction and use high-quality reagents.



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