Histohormones are biologically active substances of a peptide nature that are produced by histiocytes and have a regulatory effect on connective tissue cells.
Histiocytes are connective tissue cells that perform various functions, including synthesizing and secreting biologically active substances. Among these substances, a special place is occupied by histohormones that regulate the metabolism of connective tissue cells.
To date, several histohormones have been identified. The most studied are fibronectin, prostaglandins, interleukins and other cytokines. They regulate the proliferation, differentiation and function of fibroblasts, osteoblasts, chondrocytes and other connective tissue cells.
Thus, histohormones play an important role in maintaining the homeostasis of the body’s connective tissue. Their research is promising for understanding the mechanisms of tissue regeneration and developing new approaches to the treatment of diseases of the musculoskeletal system.