Hynalgin

Country of origin: Poland, ICN Polfa Rzeszow Poland
Pharm-Group: Drugs for the treatment of trichomoniasis, amoebiasis and other protozoal infections

Manufacturers: Polfa, Rzeszowskie Zaklady Farmaceutyczne SA (Poland), ICN Polfa Rzeszow (Poland)
International name: Metronidazole + Chlorquinaldone
Dosage forms: vaginal tablets
Ingredients: Chlorquinaldone, metronidazole, citric acid.

Indications for use: Infectious and inflammatory diseases of the vagina caused by pathogens sensitive to the drug: vaginitis, bacterial, trichomonas, fungal, mixed or prevention.

Contraindications: Hypersensitivity to metronidazole, chlorquinaldone and other ingredients included in vaginal tablets, blood diseases, leukopenia (including history), organic lesions of the central nervous system, impaired coordination of movements, liver failure, pregnancy, breastfeeding.

Side effects: Itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge without odor or with a faint odor, frequent urination; after discontinuation of the drug - development of vaginal candidiasis; burning sensation or irritation of the penis in a sexual partner; headache, dizziness, leukopenia or leukocytosis; nausea, changes in taste, metallic taste in the mouth, dry mouth, decreased appetite, abdominal cramps, vomiting, constipation or diarrhea; allergic reactions: urticaria, itching of the skin, rash. Urine may turn red-brown in color due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole.

Interaction: Metronidazole enhances the effect of indirect anticoagulants (for example warfarin), which leads to an increase in the time of prothrombin formation. Concomitant use with disulfiram can lead to the development of various neurological symptoms (depression of consciousness, development of mental disorders), therefore Ginalgin should not be prescribed to patients who have taken disulfiram over the past 2 weeks. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects. When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase. It is possible that the effect of Ginalgin may be reduced under the influence of barbiturates, because inactivation of metronidazole in the liver accelerates.

Overdose: No data available.

Special instructions: Avoid drinking alcohol. During treatment with the drug, it is recommended to abstain from sexual intercourse. If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or with its long-term use, monitoring of a general blood test is necessary. Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test). Patients, especially drivers of vehicles and people operating other machinery, should be alerted to the possibility of dizziness associated with taking the drug.

Literature: Encyclopedia of Medicines, 2005.