Isoniazid

Isoniazid (Tubazid, ftivazid, etc.) is an anti-tuberculosis drug that has a selective neurotoxic (convulsive) effect.

In case of overdose, isoniazid causes:

1. Dyspeptic disorders (nausea, vomiting, abdominal pain)
2. Headache, dizziness, paresthesia, dry mouth, tremor, ataxia, shortness of breath, bradycardia followed by tachycardia
3. Dysuric disorders, proteinuria
4. In case of severe poisoning - epileptiform type convulsions with loss of consciousness and respiratory distress
5. Possible development of toxic nephropathy, hepatopathy
6. Severe metabolic acidosis

Treatment:

1. Gastric lavage, administration of activated carbon, saline laxative. Forced diuresis with blood alkalization. Hemosorption or hemodialysis.

2. Intravenous administration of pyridoxine.

3. Administration of diazepam with muscle relaxants, artificial ventilation. Correction of acidosis with 4% sodium bicarbonate solution.