Captopril-FPO: Russian antihypertensive drug
Captopril-FPO is an antihypertensive drug belonging to the pharmacological group of angiotensin-converting enzyme (ACE) inhibitors. It is produced in Russia and produced by the Obolensky pharmaceutical enterprise.
The active ingredient of the drug is captopril, a widely known international name. Captopril-FPO also has various synonyms, including Alkadil, Angiopril, Angiopril-25, Apo-Capto, Acetene, Blockordil, Vero-Captopril, Gen-Captopril, Capocard, Capoten, Capofarm, Capril, Capto, Captopril, Captopril 25, Captopril Hexal , Captopril OF, Captopril Stada International, Captopril-Akos and Captopril-Ak.
Captopril-FPO is available in the form of tablets with a dosage of 25 mg. The drug is used for the treatment of arterial hypertension (including mono- and combination therapy), congestive heart failure, cardiomyopathy, left ventricular dysfunction in a stable condition in patients after myocardial infarction, as well as diabetic nephropathy against the background of type 1 diabetes mellitus.
However, before using Captopril-FPO, contraindications must be taken into account. This includes hypersensitivity to the drug, a history of angioedema with previous use of ACE inhibitors, hereditary or idiopathic angioedema, primary hyperaldosteronism, pregnancy and breastfeeding. There are also restrictions for use in cases of leukopenia, thrombocytopenia, aortic stenosis or other obstructive changes that impede the outflow of blood from the heart, hypertrophic cardiomyopathy with low cardiac output, severe renal dysfunction, bilateral renal artery stenosis or stenosis of the artery of a single kidney, the presence of a transplanted kidney, hyperkalemia and childhood.
Like other medicines, Captopril-FPO may have side effects. From the nervous system and sensory organs, fatigue, dizziness, headache, central nervous system depression, drowsiness, confusion, depression, ataxia, convulsions, numbness or tingling in the extremities, visual and/or smell disturbances may occur. The cardiovascular system and blood may react with hypotension, including orthostatic, angina pectoris, myocardial infarction, cardiac arrhythmias (atrial tachycardia or bradycardia, atrial fibrillation), palpitations, acute cerebrovascular accident, peripheral edema, lymphadenopathy, anemia, chest pain, pulmonary embolism, neutropenia, agranulocytosis (in patients with impaired renal function, against the background of collagenosis), thrombocytopenia and eosinophilia. The respiratory system may respond with bronchospasm, shortness of breath, interstitial pneumonitis, bronchitis, and a nonproductive dry cough. The gastrointestinal tract may exhibit anorexia, taste disturbance, stomatitis, ulcerative lesions of the oral and gastric mucosa, xerostomia, glossitis, difficulty swallowing, nausea, vomiting, dyspepsia, flatulence, abdominal pain, constipation or diarrhea, pancreatitis, damage to the liver and bile ducts. From the kidneys and urinary system, renal dysfunction may occur, including oliguria, anuria, proteinuria, increased creatinine and blood nitrogen levels, hyperazotemia, hyperkalemia, hyponatremia, unstable kidney syndrome, glomerulonephritis and interstitial nephritis. From the endocrine system, hyperkalemia, hyponatremia, unstable kidney syndrome, as well as changes in thyroid function may occur. Side effects may also include allergic reactions, myalgia, arthralgia, fever, skin erythema, angioedema, photosensitivity, sweating, weight gain, hypoglycemia or hyperglycemia, hyperuratemia, hyperlipidemia, hypercholesterolemia, increased alkaline phosphatase activity, increased bilirubin and creatine phosphokinase levels. blood, eosinophilia, anemia, thrombocytopenia, leukopenia, agranulocytosis, myasthenia gravis and myopathy.
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