Karyogamy is a type of reproduction in prokaryotes and eukaryotic cells until the end of the meiotic process, occurring by conjugation or in other cases by exo- and endocytosis of their extranuclear substance by direct approach and absorption after the loss of flagella in some cells and vice versa, by attraction of particles of pili and adhesins in others. In the karyogamous state, cells can grow, divide, and undergo DNA synthesis for a long time. Karyogamy should not be called the processes of division, development and cytokinesis (including meiosis), regardless of the time of their appearance in the life cycle of the cell. Below is a brief history and information