Kininogens

Kininogens are the general name for glycoproteins that are synthesized mainly in the liver and converted into kinins (vasoactive peptides) under the influence of kininogenin. Kinins play an important role in the regulation of various physiological processes such as blood circulation, blood pressure, regulation of hormone secretion, etc.

Kinins are derivatives of amino acids such as arginine and lysiline, which are linked to glycine and proline. Kininogenins are proteins that catalyze the conversion of kinins from an inactive to an active form. These proteins can be found in a variety of tissues, but the most common kininogenins are kallikrein, bradykinin-converting enzyme (BCE), and other plasma proteins.

Kininogens and kininogenins play an important role in many physiological processes. For example, kininogens may be involved in the regulation of vascular tone and blood pressure, as well as in the regulation of the secretion of various hormones. In addition, kinins can influence the development of certain diseases, for example, the development of atherosclerosis, inflammatory processes and other diseases.

Research in the field of kininogens and kininogenins is of great importance for understanding the mechanisms of regulation of various physiological processes in the body. Studying these compounds may help develop new treatments for diseases associated with dysregulation of blood circulation and hormone secretion.

Kininogens are the general name for glycoproteins that are synthesized primarily in the liver and converted to kinins by kininogens. Kinins are a group of peptide hormones that play an important role in the regulation of many physiological processes in the body.

Kinins are important regulators of vascular tone, heart rate, blood pressure, metabolism and other processes. They are also involved in the regulation of inflammatory reactions, wound healing and other processes.

Kinin synthesis occurs in the liver under the action of kininogens - enzymes that activate kininogen and convert it into kinin. Kininogens include various proteins such as plasma factors, blood clotting factors, growth factors and others.

In the human body, kininogens play an important role in many processes, including the regulation of blood pressure and heart rate. They may also be associated with the development of certain diseases, such as hypertension and cardiovascular disease.

The study of kininogenic mechanisms is important for the development of new treatments for various diseases. For example, some studies have shown that kininogenic enzyme inhibitors may be effective in treating hypertension and other diseases.

Thus, kininogens are important regulators of many physiological processes, and their study may lead to the development of new methods for treating diseases.