Mast Cell

Mast Cell: functions and significance in the body

Mast Cells are large cells found in the connective tissue of humans and animals. They play an important role in the body's immune system, protecting us from infections and other harmful influences.

Mast cells were first described in 1877 by French histologist Paul Ehrlich, who discovered them in lung and skin tissues. He named them "Tuchzellen" (meaning "down cells" in German) because of their multiple cytoplasmic granules.

Mast cells contain many granules that are saturated with biologically active substances such as histamine, heparin and other inflammatory mediators. During inflammatory processes or allergic reactions, mast cells release substances contained in the granules, causing characteristic symptoms such as hives, itching, swelling and other manifestations of allergic reactions.

In addition, mast cells play an important role in protecting the body from infections. They release cytokines and other biologically active substances that attract immune cells to the site of infection and help eliminate pathogens. In addition, mast cells can phagocytose and destroy bacteria and viruses.

Mast cells also play an important role in tissue remodeling processes, such as vascular growth and regulation of the activity of cells responsible for tissue growth and development.

Although mast cells play an important role in protecting the body, their release of biologically active substances can lead to unwanted effects such as allergic reactions and inflammation. Therefore, controlling the release of inflammatory mediators is the goal of many drugs used in the treatment of allergic diseases and other inflammatory processes.

In conclusion, mast cells are important players in protecting the body from infections, allergic reactions and other harmful influences. They play an important role in inflammation and tissue remodeling, and their dysregulation can lead to various pathologies. Therefore, studying the functions and regulation of mast cells is an important task for the development of new methods of treatment and prevention of various diseases.

A mast cell is a large cell that is present in connective tissue. It has many large cytomembrane granules that contain histamine, serotonin and heparin. These cells play an important role in the body's allergic and inflammatory reactions.

Mast cells are formed in the body as a result of the division of connective tissue cells that migrate to tissues with high levels of inflammation. As a result of this process, many granules filled with histamine and serotonin appear in mast cells. These substances are inflammatory mediators that are activated in response to various irritants, such as allergens, toxins, bacterial and viral infections, injuries, etc.

When mast cells are stimulated, they release these mediators, which leads to the development of allergic and inflammatory reactions. Mast cells may also play a role in shaping the body's immune response to infections and other diseases. In addition, mast cells may be involved in the development of certain types of cancer.

To treat allergic and inflammatory diseases, drugs are used that block the production of histamine and serotonin by mast cells. This can be achieved both by inhibiting enzymes that are involved in the synthesis of these substances, and by reducing the number of mast cells in tissues. However, these treatments are not always effective and side effects are possible.

In general, mast cells play an important role in maintaining homeostasis and protecting the body from various diseases. However, their excessive activation can lead to the development of allergies and inflammatory reactions, which require monitoring and treatment.

Mast cells or mast cells are large cells (diameter 15-20 microns) that are present in connective tissue and have the ability to phagocytose. They have many large cytoplasmic granules containing histamine, serotonin and heparin. These substances are released into the blood during inflammation and allergic reactions.

Mast cells have several functions. Firstly, they participate in the formation of the body’s immune response to various irritants. Secondly, they can promote wound healing and tissue repair. Third, they play an important role in regulating blood pressure and blood sugar levels.

However, in some diseases, such as bronchial asthma, atopic dermatitis, psoriasis and others, mast cells can cause allergic reactions and inflammation. This is because they can release histamine in excess amounts, which leads to the development of allergy symptoms.

Thus, mast cells play an important role in the functioning of the body and may be associated with various diseases. However, in order to avoid the development of allergic reactions and inflammation, it is necessary to control the number of these cells in the body and monitor their activity.