Rosette-forming cells

Rosette-forming cells are lymphocytes that have antigen-binding receptors and can form agglutinins with antigens of other cells, such as red blood cells. This process is called agglutination and results in the formation of rosettes of red blood cells. Rosette cells play an important role in the immune system because they recognize and destroy foreign cells such as bacteria and viruses. They are also involved in protecting the body from infections and tumors.

The formation of rosettes occurs due to the interaction of antigen recognition receptors of lymphocytes and erythrocyte antigens. Lymphocytes secrete antibodies that bind to antigens on the surface of red blood cells. The red blood cells then begin to agglutinate, forming rosettes that are visible under a microscope. This process allows lymphocytes to recognize and destroy infected cells.

Rosette-forming cells can be found in the blood of patients with various diseases, such as infectious diseases, autoimmune diseases and malignancies. The study of rosette cells is an important tool for diagnosing and monitoring these diseases.

In general, rosette cells play a key role in the body's immune response to antigens. Their research could help develop new treatments for various diseases and improve the effectiveness of the body's immune response to infections and tumors.

Rosette cells are an important phenomenon in immunology that was brought to the attention of Edmond von Hannsteen in 1882. These cells form on the surface of red blood cells when they come into contact with antigens - proteins and other molecules contained in the blood. When red blood cells interact with antigens, the process of agglucination occurs, that is, the cells stick together. Under the influence of a microscope, the resulting clusters of red blood cells resemble rosettes.

Lymphocytes that actively react to antigens have the ability to recognize foreign proteins and prevent their penetration into the human body. However, to detect and destroy antigens, lymphocytes must be in contact with them. This is what explains the formation of connections between cells and subsequent agglutination due to increased electrical interaction between antigenic sites and binding centers on the lymphocyte membrane.