Cutaneous-Venous Coefficient

Cutaneous-Venous Coefficient: definition and application

The cutaneous-venous ratio (CVC) is a toxicometric indicator used to estimate the ratio of the average lethal doses of a certain toxic substance to animals of the same species when applied to the skin and when administered intravenously. EFQ is an important parameter used in assessing the toxicity of chemicals and in developing safety strategies.

To understand how CVC works, you need to understand two indicators: the average lethal dose (LD50) and the route of administration. LD50 is the dose of a substance that causes death in 50% of animals in a given group when given by a particular route of administration. The route of administration can be different: dermal, intravenous, oral, etc.

Typically, the CVK is calculated by dividing the LD50 obtained from intravenous administration by the LD50 obtained from dermal administration. Thus, the CVC shows how much more toxic a substance is when administered intravenously compared to dermal administration.

The CVC is important in determining a safe dose for humans and in assessing the toxicity of a substance. If the CVC is low, this indicates a high toxicity of the substance when administered intravenously, which can lead to dangerous health consequences. In this case, it is recommended to reduce the dose of the substance or use a different route of administration.

However, one should not rely solely on the ECC when assessing the toxicity of a substance. Other factors, such as the duration of contact with the substance, its degree of solubility, etc., can also affect its toxicity. In addition, the CVC may vary depending on the species of animal on which the experiments are carried out and the dose of the substance.

In conclusion, the Cutaneous Venous Ratio (CVC) is a toxicometric index used to estimate the ratio of the mean lethal doses of a given toxic substance to animals of the same species when applied to the skin and when administered intravenously. The CVC is important in determining a safe dose for humans and in assessing the toxicity of a substance, but it should not be relied upon alone when assessing the toxicity of a substance.

The skin-venous coefficient (SVK) is a toxicometerological indicator that characterizes the ratio of average amounts of a substance entering the body in direct contact with the skin and through the circulatory system. In other words, the KVK shows how toxic a substance is when administered