Lymphocyte Bone Marrow

Lymphocytes - white blood cells - are formed and differentiated in the red bone marrow and lymph nodes. They make up the bulk of circulating lymph. As a result of differentiation, the differentiation of B lymphocytes occurs in several stages:

Transition period - Langerhan cell. At first, the nucleus is located inside the cytoplasm; by the end of the period, the nucleoli disappear. The cells lose their characteristic agranulocytic nucleus. The final version of the lymphocyte is no different from other types of granular cells, but they are still represented only by cytoplasm. Somewhat later, at the end of the Langerhan period, a characteristic agranuloid mononuclear nucleus is formed.

The borderline period is a large undulating lymphoid cell with a cytoplasmic column (such a cell turns into a plasma cell).

Function: humoral immune system, ensuring the destruction of pathogenic microorganisms and malignant cells.

**Bone marrow lymphocytes (B).**

They develop in the hematopoietic tissue of the body.

* Small cells with an oval nucleus and borders of arbitrary shape. Inside the nucleus there is chromosomal material in the form of heterochromatin and nucleoli. The nucleus is surrounded by a transparent zone of cytoplasm, in which clumps of NMF (nuclear matrix - fibrillar structures), various inclusions - mitochondria, and the Golgi complex are located. The location of NMF is chromatin, the structure of chromosomes, around which, like peri-growths, threads of the nuclear matrix are located, intertwining in places. Each B lymphocyte cell has 2-3 nucleoli located near the center of the cell. The cell is covered with mucus produced by stromal cells. Functions: bone-forming, barrier. Transports ions, oxygen and other substances