Lofepramine

Lofepramine is a tricyclic antidepressant (TCA) that is used to treat mental disorders including depression, anxiety, panic disorder, insomnia, and others. It can also be used to treat pain caused by various diseases such as arthritis or migraines.

Lofepramine works by blocking the reuptake of serotonin and norepinephrine in the brain, resulting in increased levels of these neurotransmitters and improved mood, anxiety and pain.

Side effects that may occur when taking lofepramine include dry mouth, drowsiness, dizziness, constipation, and difficulty urinating. Side effects may also occur in the form of increased blood pressure, palpitations, blurred vision and flushing of the face.

It is important to note that lofepramine should not be taken without consulting your doctor as it may interact with other medications and cause serious side effects. Before you start taking lofepramine, you must undergo a full medical examination and follow your doctor's instructions.

Lofepram is an antidepressant drug from the group of typical antidepressants for the treatment of depression. But most psychiatrists and neurologists know about this. Therefore, I present information about the action and use of loferamine briefly.

According to the World Health Organization (WHO) classification, lofepram belongs to category A1 (with a clear action and well-studied effects on the human body). The drug is indicated for all types of depression in the form of tablets of 25-75 mg (depending on the severity of symptoms of mental disorder) and in the form of intravenous injections. The dosage is strictly individual and depends on the patient’s age, type of depression and concomitant diseases. I strongly recommend not to self-medicate with this medication. Among the side effects, I note that, along with other antidepressants (with increasing doses), it can cause disturbances in eye accommodation (perception of nearby objects) and insomnia. The use of the drug must be combined with symptomatic treatment. Before starting use, you should also consult a doctor.

Lofepramine is a tricyclic (TCA) antidepressant drug used to treat depressive disorders (persistent loss of mood, usually expressed as a subjective feeling of sadness, depression, hopelessness) of various etiologies. The drug appeared after development in 1957. One of the oldest modern drugs in the group of tricyclic antidepressants. These drugs are used

Lofepramine (Lofepramidum), also lofepramine, is a tricyclic antidepressant. Produced under the trade names “Gama-Nil”, “Adaline”, “Fluoxetine”, “Palinol”. It is prescribed orally or intravenously in short infusions, is well absorbed, and does not accumulate. Duration of action - 8-15 hours.

The main antidepressant mechanisms of action of lofepramine are due to its inhibition of the reuptake of tricyclic serotonergic (5-HT) and adrenergic amines (AIH and NAI), as well as blockade of histamine H3 receptors. An important role in the mechanism of action is played by the alpha-adrenergic blocking effect, somewhat more pronounced than that of amitriptyline, as well as the antihypoxic effect, especially in relation to the retina. During treatment with lofepramine, depression helps to suppress the release of glutamate and hypoxanthine in the synapses of the hippocampus and cerebral cortex, which contributes to the weakening of