Malaria Unpersistent

Malaria "Unstable": why does this disease remain a challenge for world medicine?

Malaria is one of the most common and dangerous diseases in the world. This infectious disease is caused by parasitic protozoa transmitted through mosquito bites. Although malaria is considered a controlled disease, it continues to be a challenge for global medicine. This is especially true for a form of malaria known as “non-persistent”.

Non-persistent malaria is a form of malaria that is characterized by significant fluctuations in population prevalence, both within the transmission season and from year to year. In addition, there is generally low herd immunity to this form of malaria. This means that even in cases where the majority of the population lives in areas where malaria is common, herd immunity cannot prevent outbreaks.

The reasons for the “instability” of malaria are not fully understood. However, one reason may be due to mutations in the genome of the parasite that causes the disease. These mutations can change the appearance of the parasite, making it difficult for the human immune system to recognize it. Thus, the body cannot mount an effective immune response to the infection.

Another reason is related to climate change and environmental conditions in places where malaria is common. Global warming and changes in precipitation patterns could lead to changes in the ranges of mosquito vectors and the spread of the disease to new regions. In addition, environmental degradation may contribute to the development of mosquito populations, increasing the risk of transmission.

Despite all the efforts aimed at combating malaria, this disease still remains a challenge for world medicine. Although effective methods for preventing and treating malaria exist, they are not always available to everyone who needs them. Therefore, to defeat malaria it is necessary to continue research and develop new technologies that will more effectively control the spread of this dangerous disease.

Plasmodium parasites are transmitted to humans by the bite of infected Anopheles mosquitoes. But not every bite becomes infected. The absence of laboratory or clinical manifestations is a symptom of parasitemia. Therefore, people who have had at least one case of infection consider themselves immune. However, there is no immunity after one bite, only short-term parasitism. If we talk about mass endemicity, the unstable transmission of malaria causes significant fluctuations in incidence throughout the year - seasonal peaks and valleys occur. To prevent malaria, it is necessary to control mosquitoes. This can be done with the help of disinfestation and the use of mosquito nets. An equally important role is played by the use of repellents before going outside. However, it should be remembered that preventive measures are not a panacea, since they do not guarantee complete protection against malaria infection.