Country of origin - Russia
Pharm-Group - Alkaloids and other cytostatic agents of plant origin
Manufacturers - Lance-Pharm (Russia)
International name - Vinorelbine
Synonyms - Vinelbin, Vinkarelbin, Navelbin
Dosage forms - concentrate for the preparation of infusion solution 10 mg/ml
Composition - Active substance - vinorelbine.
Indications for use: Inoperable non-small cell lung cancer, breast cancer, ovarian cancer.
Contraindications - Impaired liver and kidney function, granulocytopenia, pregnancy, lactation.
Side effects - Granulocytopenia, anemia, nausea, vomiting, constipation, decreased osteotendon reflexes, paresthesia, weakness in the lower extremities, jaw pain, paralytic ileus, bronchospastic reactions, alopecia, phlebitis at the injection site.
Interaction - The antitumor effect is enhanced by cisplatin.
Overdose - Symptoms: severe granulocytopenia with the development of neutropenic fever and superinfection. Treatment: transfusion of a preserved mixture of granulocytes, administration of colony-stimulating factors to improve granulocytopoiesis, antibacterial therapy for superinfection.
Special instructions - Dynamic monitoring of peripheral blood parameters and biochemical indicators of liver function is recommended.
Literature - Encyclopedia of Medicines, 2004