Ointment Homogeneous

Suspension ointment, ointment, dosage form, in the manufacture of which drugs are distributed in a liquid medium (suspended). The dosage form for application to the skin contains active substances in microspheres, insoluble in water, but soluble in lipids, so the oils remain unchanged, and the medicinal substances disintegrate into small particles (colloidal or submicroscopic), there is no interface between the phases of the medicinal substance and the oil, in addition, emulsions of varying viscosity, concentration and specific gravity can be formed, depending on the type of fatty base (vaseline, organosilicon oil) and the percentage of the medicinal substance (usually no more than 5% for the face). Unlike a suspension, a smaller amount of dispersed phase is obtained in a homogeneous dispersed phase. Ointments have a low viscosity, are easily spread on the skin and also rubbed into it well. The fatty composition of ointments facilitates their penetration into the body and prevents them from being washed off under the influence of water. Ointments are used as a base and solvent for substances that form emulsions (liniments, lotions). Intraintestinal administration of liniments is difficult, so they are used only in the form of ointments, despite the fact that they have a more viscous consistency. The pharmacological characteristics of the ointment are usually described using technological characteristics - plasticity, homogeneity, uniform distribution of the drug substance, the ability to form and contain a fatty base, as well as adhesion (adhesion to the mucous membrane), etc. The pharmacological action of the ointment (the set of effects) consists of the action of medicinal drugs substances and physicochemical properties and fat bases. Homogeneous ointments are usually made on the basis of petroleum jelly or other fatty

Homogeneous ointment - ointments without visible heterogeneity of the internal structure, which are a homogeneous thick mass, sometimes slightly granular, without a secretory effect, but having the property of melting in water. They are characterized by the absence of an interfacial interface between the drug substance and the ointment base. Homo