Megakaryocyte

A megakaryocyte is a large bone marrow (BM) cell that plays an important role in the production of platelets. This cell has a diameter of 35 to 160 micrometers and is the largest cell in the CM.

Structure

Megakaryocytes are irregularly shaped and divided into many lobes. Inside the cell there is a large amount of cytoplasm, stained with Romanowsky dye. In the cytoplasm you can see red granules called platelets.

Functions

The main function of megakaryocytes is to produce platelets, which are the cells responsible for blood clotting. Platelet formation occurs as a result of the division of megakaryocytes.

Megakaryocytes also participate in the regulation of hematopoiesis and maintain the balance between the formation of new platelets and their destruction.

In general, megakaryocytes play an important role in maintaining the health of the circulatory system and protecting the body from blood loss.

Title: “Megakaryocytes: structure and role” Author: [Name]

Introduction

A megakaryocyte is a bone marrow cell. From such cells platelets are formed, which participate in the process of blood clotting. Despite the apparent complexity of their structure, megakaryocytes play an important role in maintaining the integrity of the circulatory system. This article is devoted to describing the structure and function of these cells.

Megakaryocytes and their functions

A special feature of the megakaryocyte is its large size, which reaches 35 - 160 micrometers in diameter. It has an irregular shape and the core is divided into several lobes. Inside the cell there are many red granules that form a large cytoplasm. It is dyed using Roman-Markov dye in a pale blue color. Under a microscope, red granules are clearly visible.

The main function of megakaryocytes is to produce platelets

Human megakaryocytopoiesis is a complex process involving bone marrow stem cell proliferation and differentiation of megakaryocytes into megakaryocytes through successive intermediate steps. The result of this process is the formation of a huge number of megakaryocytes in the bone marrow, measuring up to 30 microns in size and weighing more than 700 million millionths of a gram.

Megakarocytopoiesis is genetically controlled and regulated by signaling pathways. The SHC/MAPK signaling pathway controls the dynamics of proliferation and differentiation of the megakaryopoietic stroma, and one of the proteins of the WNT signaling pathway regulates the rate of stages along the differentiation pathway.

When detected, a megakaryocyte is usually removed from the bone marrow in the early stages of differentiation, becoming a mechanocarya, then, upon maturation, divides and produces a large number of derivatives - platelets. Platelets are platelets of blood that are formed in the red bone marrow and peripheral blood. Small, colorless corpuscles (from the Greek word for dehydration, "tiny") platelets periodically eat away at their outer membrane, which becomes a single layer of cells from the inside, forming a layer to protect the blood vessels. During these events, X-shaped crosses form in small numbers, the inner walls are closed and greater strength appears around them as blood coagulates from wounds or other damage.