Metastasis Osteolytic

Osteolytic metastasis is a term used in medical terminology to describe the process of spread of cancer cells from the primary tumor site to the skeletal bones. This process occurs through the bloodstream and lymph and can lead to the destruction of bone tissue and the formation of foci of bone destruction.

Osteolytic metastases can occur both in primary malignant tumors and in metastatic bone lesions. The most common primary tumors that can lead to osteolytic metastases are breast cancer, lung cancer, prostate cancer, and kidney and thyroid cancer.

The main symptom of osteolytic metastasis is bone pain, which can be severe and lead to loss of function of the affected bone. Bone deformities, bone loss, pathological fractures, and other bone changes may also occur.

Treatment of osteolytic metastases depends on the type of tumor, stage of the disease and the general condition of the patient. In some cases, surgery, radiation therapy, or chemotherapy may be required. In other cases, symptomatic treatment, such as pain medications and exercise, may be sufficient.

It is important to note that osteolytic metastases are a serious disease that can lead to disability and even death of the patient. Therefore, if osteolytic metastases are detected, you must immediately consult a doctor for diagnosis and treatment.

Osteolytic or osteoclastic metastasis (Latin metasta-sis “porous” and osteoli-tica (stack)) is a malignant bone lesion characterized by atypical proliferation of osteoblasts in the area of ​​​​the metastatic tumor and, as a consequence, degenerative destruction of the bone matrix. Most often, metastasis by osteoblastosis is detected in malignant tumors of the liver, less often in other internal organs. Typical sites for metastatic tumors in the bone are the metaphysis of long tubular bones, the spinal column and, in isolated cases, the pelvic bone.

Pathological anatomy Osteolytic tumors are characterized by destruction of metaphyseal cartilage, distal to which the process of bone remodeling predominates over tumor osteoclastic activity, therefore the terminal edge of the tumor is represented by a zone of regenerative trabeculae that do not have time to grow until a completely resorbed tumor. In their area there is an extensive area of ​​revascularization. Typically, newly formed blood vessels in this area penetrate into the area of ​​bone remodeling, often affecting the thickness of the neoplasm. It should be noted that in this localization this picture is characteristic of most osteolytic tumors, with the exception of osteogenic sarcomas of various origins, which are characterized by a loose structure of the lesion. Infiltration of the tumor by tumor cells has the appearance of a malignant vascular canal. For osteo