Methysergide

Methysergide: Migraine prevention and diarrhea treatment

Methysergide, whose commercial name is Deseril, is a medicinal substance used to prevent severe migraine attacks and stop diarrhea associated with various tumors of the digestive system. This medication is taken orally and has properties that can significantly relieve the symptoms of these conditions. However, before you start using methysergide, you should consult your doctor and strictly follow the dosage recommendations.

Methysergide belongs to a group of drugs known as serotonin agonists. It affects the blood vessels of the brain, changing the activity of serotonin receptors. This helps reduce vasoconstriction and inflammation, which is one of the main causes of migraine attacks. With continuous use of methysergide, it can reduce the frequency and intensity of migraine attacks.

In addition, methysergide may be effective in treating diarrhea associated with tumors of the digestive system. It acts on the nervous system and blood vessels, helping to reduce secretions and peristalsis in the intestines, which can lead to a decrease in the frequency and intensity of diarrhea.

However, like any other medicine, methysergide can cause side effects. Some of these may include indigestion, dizziness and drowsiness. In some cases, abdominal pain, nausea, vomiting, general weakness or allergic reactions may also occur. If you experience any side effects while using methysergide, you should consult your doctor immediately.

It is important to note that methysergide must be prescribed by a doctor and taken strictly as recommended. The dosage of methysergide may vary depending on the characteristics of the patient and the type of disease. You should never exceed the recommended dose or duration of use without consulting your doctor.

In conclusion, methysergide (deseril) is a medicinal substance whose use may be useful in preventing severe migraine attacks and treating diarrhea associated with tumors of the digestive system. However, you should consult your doctor before starting to use this drug, as methysergide may cause side effects and requires strictly controlled dosage.

Antiemetic, serotonin 5-HT3 receptor antagonist. Suppresses vomiting caused by apomorphine, Lysol, apomorphic acid. It has an antiemetic effect that is not associated with central nervous system depression.

When taken orally, it is quickly and completely absorbed. Cmax in plasma is reached after 0.5–1 hour. Bioavailability is approximately 90%. Css in plasma is achieved within 24 hours.

Plasma protein binding is high (98%). Vd - about 1 l/kg. Metabolized in the liver by N-demethylation. T1/2 - 4-6 hours. Excreted by the kidneys (50%) and through the intestines (40%) unchanged and in the form of metabolites.

The main side effects are dizziness, drowsiness, headache, tremor, asthenia, mydriasis, dry mouth, diarrhea, dyspepsia, tachycardia, hypotension. Less common side effects may include seizures, paresthesia, tinnitus, blurred vision, changes in taste, hyperthermia, hypothermia, cardiovascular abnormalities, ECG changes, skin rash, hematopoietic abnormalities, liver function abnormalities, changes in laboratory values. .

Methysergide is contraindicated during pregnancy and lactation (breastfeeding), as well as in children under 3 years of age.

Use for impaired liver and kidney function is contraindicated.

Methysergide is a drug that has a pronounced antiserotonin effect. This substance belongs to the group of serotonin receptor antagonists. By disrupting the activity of these receptors, the drug eliminates excessive activity of the sympathetic nervous system, leading to various malfunctions and disorders in the body.

In medical practice, methysergide is used if necessary to quickly and effectively reduce the frequency