Mesoderm Lateral

What is Lateral Mesoderm?

The lateral mesoderm is a functional element of the germ cell, consisting of three main layers: paracells, mesenchymal cells and extracellular matrix. This layer is one of the first developing layers of the embryo, which gives rise to a number of tissues and organs of the embryo. All processes of development and morphogenesis in embryogenesis depend on the size, shape and location of the lateral mesoderm, as well as on the functioning of its cell.

Clinical significance of lateral mesenchyme

In biology, the development of the embryo and embryogenesis is based on the sequential differentiation of the mesoderm and the interaction of several sections of the mesoderm for the development of specialized tissue. Many cases of microcephaly are associated with mutations in one or more strands of the gene encoding the CHS-11B protein, which is necessary for proper differentiation of the lateral mesenchymal layer. Lateral mesenchymal tissue is one of the fundamental basic components.

Removal of parts of the mesenchymal layer can lead to the development of one or more of the following conditions:

a) The mosaic form of microcephaly occurs when certain areas within the mesenchymal layer are not developed correctly. This can lead to a mismatch between the stages of development of the corresponding parts of the brain and the formation of a small brain with poor development of cortical structures. Such patients usually have skull damage, delayed development of the cerebral cortex, increased intensity of intrauterine development, myelography of disorders of various membranes and nervous tissue, a high risk of agenesis of the lateral thalamus of the optic tract and eye abnormalities (posterior abnormal fixed rotation, etc.) b) Fronto-orbital agenesis occurs when the anterior region forms during embryonic and postnatal development. This defect is associated with impaired differentiation of the third layer of the lateral medullary plate and the development of both sections without connection. In this state