Myocarditis Trypanosomal

Myocarditis is an inflammatory lesion of the myocardium, or heart. In most cases, myocarditis is considered in the context of autoimmune pathology.

Myocarditis caused by *T. cruzi*, was called “rheumatism without rheumatic status.” Tryponosome multiplies in mononuclear phagocytes and causes activation of the cellular immune system (T cells and macrophages), which is accompanied by migration and local release of a large number of cytokines and chemokines, incl. interleukin-2, TNF-α, IL-6, IL-15, IL-13, tumor necrosis factor alpha, etc., especially with intensive parasite invasion of target cells, sequestration of trichomonas or their lysis, which leads to damage to neighboring cardiomyocytes. This contributes to the development of giant cell myositis. Patients develop more severe symptoms than with cardiovascular bedbug infection, likely due to the more severe damage to cardiomyocytes associated with cardiac trypanosomiasis. As a result of infectious and immune effects, parasites aggravate the degree of pathomorphological changes that develop in Takotsubo myocarditis. Subsequently, against this background, a proarrhythmogenic background is created that can lead to arrhythmias that form in the interval between infectious

Article - Tryponomasomal myocarditis.

Myocarditis and tryponosomes are one of the common diseases that disturb the cardiovascular system. Every year the number of patients with myocarditis with a similar infection increases several times. The causative agent of the disease is various tryponosomes, they come from carriers - parasites. Caused by the presence of microphages in the blood, a viral infectious disease. The kinetics of myocardial inflammation determines the rate of progression of the disease. Clinical manifestations of myocarditis tryponomus are not specific, so they can occur either in isolation or be combined with other diseases.