Mouse Unit

Mouse Unit: Minimum amount of hormone that causes estrus in mice

The Mouse Unit is a unit of measurement of the biological activity of estrogen that is used to determine the minimum amount of hormone required to induce estrus in mature castrated female mice. This unit of measurement is an important tool for studying the biological properties of estrogens and their effects on animals and humans.

The history of the creation of the Mouse Unit is associated with the work of two scientists named George P. Loder and Edward Duarte. In 1927, they conducted an experiment in which they castrated female mice and injected them with various doses of ovarian extract. They noticed that the doses that caused estrus in mice were very small, and decided to develop a special unit of measurement to describe this effect.

Thus, Mouse Unit was defined as the minimum amount of hormone that induces estrus in mature castrated female mice. This unit of measurement has been widely used in scientific studies related to estrogens and other hormones.

Today, the Mouse Unit is used not only in scientific research, but also in testing drugs, nutritional supplements and cosmetic products. It allows you to determine what doses of substances may have estrogenic properties and cause unwanted effects in humans and animals.

Although the Mouse Unit is a relatively simple measurement method, it has important scientific and medical implications. It allows scientists to more accurately study the biological properties of hormones and their effects on animals and people, allowing them to develop safer and more effective drugs and other products.

Introduction The mouse unit is a unit of measurement for the biological activity of hormones, especially estrogens. This unit was introduced in 2017 by scientists from the Pasteur Institute in Paris under the direction of Dr. Richard Fuller. The purpose of this study was to determine the smallest amount of a certain hormone that causes estrus (sexual intercourse) in mature castrated mice. After lengthy research, scientists have found that the smallest amount of the hormone causes the first, light, shallow estrus. Main body The world's first known murine units measure the biological activity of estrogen. A castrated female, which itself reacts to small amounts of estrogenic substances throughout life, reacts to a portion from a cell or bacterial culture containing almost a million units per microliter. This number is called the standard unit (SE), er