Mousepox Virus

Mouse pox virus

Like many other viruses, the Mousepox virus was discovered in the mid-20th century. It was described in 1952 by Japanese scientists. The Eskimos of Western Siberia were the first people to isolate the virus from bats. In 1968, Chinese scientists were the first to successfully infect newborn mice with the virus that causes smallpox in natural conditions. The name “mouse pox” was assigned to this disease in the early 70s. after the work of Soviet and American scientists who had already created an antiviral serum for smallpox and described the epidemiology of the disease in conditions of experimental contact between people and animals - the sources of the disease. A distinctive feature of the rabies epilemalia virus is that in an infected animal it is found only in the brain, localized in the neurons of the hippocampus and the embryonic cerebellum. In the external environment, the virus has low survival rate: when heated for 5 minutes to 60 °C, it is completely inactivated. The native virus is sensitive to proteolytic enzymes. Its inactivation when treated with trypsin occurs within 20 hours. For coronaviruses, the most significant destructive effect of drugs is boron trifluoride, mercury, azide and sulfhydryl method (viral preservatives have recently been developed that have a different structure than natural proteins) 2. So, what do we Do we know about the rabies epilemalia virus? Thanks to the efforts of scientists, many aspects of the life of the virus have been studied, from the site of replication to specific markers for the virion. Replication of the virus is possible in chicken embryos: after 16-24 hours, massive cytoplastic inclusions appear under microscopy. Subsequently, the inclusions undergo transformation - they become fragmented, and their individual sections resemble urachyli. At the same time, the amount of hematocrit increases sharply, reaching a maximum on the 5-7th day after infection. This result was obtained on an isotherm (37.4 °C). On vital media, the virus exhibits maximum activity on days 3–4 and 6–7, and at higher temperatures much earlier. However, in general, reproduction can continue in cells from the first hours after infection until the end of the incubation period. The virus reproduces only in living cells of animals, insects and plants. Reproduction of the virus in chicken plasma of the incubation cycle is not associated with the reproduction of intracellular and mitotic cells, the size of which, like their cytoplasm, increases towards the end of incubation in proportion to the culture time