Nissl Grit

Nissl stippling is a neuroanatomical feature that was described by the German neurologist and psychiatrist Nissl in 1897. This symptom is associated with the presence of small, round, dark grains in the neurons of the brain and spinal cord.

Nissl discovered this sign while studying the brain of a person who died of Alzheimer's disease. He noted that the man's brain contained numerous small granules that were darker than the surrounding tissue. Nissl hypothesized that these granules might be related to Alzheimer's disease, since he already knew that the disease was associated with loss of neurons and changes in brain structure.

However, further research has shown that Nissl grains are not specific for Alzheimer's disease and can occur in healthy people. In fact, some scientists believe that graininess may be related to the normal aging process of the brain.

Despite this, Nissl grains are an important sign in neurology and psychiatry, as they can indicate the presence of certain brain diseases such as Alzheimer's disease or other neurodegenerative diseases. In addition, granularity can also be used to study normal brain development and aging.

In conclusion, Nissl graining is an important feature that can help in the study of various brain diseases and the normal processes of brain development and aging. However, it must be borne in mind that this sign is not specific to a particular disease or condition, and its presence does not always indicate the presence of the disease.

Nissl speckle is a medical term meaning the appearance of multiple white dots on the fundus of the eye, resembling the shape of grains of rice or coffee dots. This pathological condition is a consequence of damage from pressure on the optic nerve. Granular is usually called one of the types of hemorrhages in the retina. Nissl graining can be determined using ophthalmoscopy.