Know that diseases of the anus are difficult to cure, since the anus combines the following features: it is the place of passage of feces, it is inverted and goes from bottom to top, it is very sensitive, it is located at the very bottom. Since this is a passage, feces constantly enter there, which sets him in motion, increases his suffering and deprives him of the peace that allows him to fully perceive the beneficial effects of drugs and gives nature the opportunity to improve his health, since it is upside down, it is difficult to retain drugs in it; because he is very sensitive, he often hurts, and frequent pain attracts illnesses; since he is at the very bottom, excesses easily descend to him, especially if he is disposed to accept them due to weakness caused by any damage.