Oxytetracycline

Oxytetracycline is a synthetic antibacterial drug from the tetracycline group. The pharmacological effect of the drug is due to inhibition of protein synthesis at the level of bacterial ribosomes. Has a bacteriostatic effect. Inhibits the synthesis of bacterial proteins by disrupting the contact between higher ribosomes and the target of antibiotics on deoxyribonucleic acid (DNA). Active against gram-positive bacteria - Staphylococcus spp. Streptococcus spp., as well as Clostridium spp., Actinomyces spp. Bacillus anthracis, Corynebacterium diphtheriae; some anaerobes - Clostridium tetani. The minimum inhibitory concentration (MIC) of oxytetracycline for Staphylococcus aureus is about 12.5 μg/ml. Effective in low concentrations (minimum bactericidal concentration - in the range from 0.7 to 2 mg/l). Mechanisms of resistance. There are strains of bacteria that are resistant to oxytetracycline. However, cross-resistance to this antibiotic and antibiotics from other groups is low.