Phenylethylamines

Currently, phenylethylamine is considered to be a precursor of catecholamines - dopamine and adrenaline. Although the concentration of drugs in the body is low, most of the amphetamine is eliminated outside the brain. For other ephedrine alkaloids (cocaine, methamphetamine), there is no data on their role as a brain neurotransmitter. Most evidence suggests that they inhibit norepinephrine synapses, blocking the release of catecholamine neurotransmitters (dopamine, norepinephrine) from receptor vesicles, which reduces the inhibitory effects of norepinephrine on nerve cells. Increasing the concentration of substances such as mDMA or ecstasy in the blood usually leads to an increased feeling of euphoria.