Posada-Wernicke's Disease

Posada-Wernicke Disease: Description, Symptoms and Treatment

Posada-Wernicke disease, also known as tropical splenomegaly, is a rare disorder that was first described by Argentine scientists A. Posada and R. J. Wernicke in the early 20th century. This disease is characterized by irreversible enlargement of the spleen and liver, which can lead to serious complications.

Posada-Wernicke disease is caused by the protozoan Trypanosoma cruzi, which is transmitted by blood-sucking insects such as thrips or parasitic mites. This protozoan can also be transmitted through contaminated blood or organ transplantation.

Symptoms of Posada-Wernicke disease can range from mild to severe. Some patients may not notice symptoms for many years, while others may develop serious complications. Typically, the first symptoms appear within the first few weeks or months after protozoan infection. Symptoms may include swollen lymph nodes, headache, fever, fatigue, muscle pain and rash.

With an enlarged spleen and liver, pain in the left upper quadrant of the abdomen, nausea and vomiting may occur. In more severe cases, cardiac dysfunction, problems with vision and coordination of movements, as well as other serious complications are possible.

To diagnose Posada-Wernicke disease, various tests are performed, such as a blood test for the presence of protozoan antibodies or a spleen biopsy. Treatment for this disease may include antiprotozoal medications such as nifurtimox or benznidazole, as well as symptomatic therapy to relieve pain symptoms and other complications.

Overall, preventive measures are the most effective way to prevent Posada-Wernicke disease. This may include the use of mosquito nets, protection from blood-sucking insects, screening of donated blood and organs for the presence of protozoar, and early detection and treatment of infestations.

In conclusion, Posada-Wernicke disease is a rare but serious condition that can lead to serious complications. Although treating this disease can be challenging, early detection and treatment are key to controlling this disease. Therefore, it is important to see a doctor if you experience any symptoms, especially if you have traveled to tropical countries. With proper diagnosis and treatment, you can reduce the risk of serious complications and improve the prognosis of the disease.

The problem of vitamin B12 deficiency today has become a global medical problem and is one of the pressing issues of modern neurology: about 8% of the world's adults have this deficiency, the prevalence of which is steadily increasing in developed countries and ranges from 30 to 60% or more among older people. The disease is accompanied by a complex of symptoms, among which dyspeptic disorders come to the fore. The connection between vitamin B12 deficiency and decreased intellectual performance, impaired attention and memory has been identified for a long time, and it is generally accepted to consider this a manifestation of the so-called Wernicke-Korsakoff encephalopathy or “sluggish steam.”