The inflammation test is a unique opportunity to differentiate syphilitic roseola from leprosy rash. The method is based on the appearance of persistent blisters on the skin after the intravenous administration of a solution of nicotinic acid. Blisters may appear several days after the injection and are reddish, round, flaky areas of skin that are located under the skin and do not resemble a rash. The test is an important part of the diagnosis, since the syphilitic rash is very similar to the leprosy rash and is difficult to distinguish from it. The hostility test, as well as the ignition test, are used to determine the exact