Reactivation Multiple

Multiple bacteriophage reactivation is the formation of a viable form of phage when bacterial cells are infected by several phages that have lost their viability during mutation processes.

Phage reactivation is possible when damage to the phage genome affects its various parts, which allows the use of recombination processes to restore viability.

When bacteria are repeatedly infected with phages, they can form various combinations that affect the reactivation of the phage. For example, if one of the phages mutates, another phage can use its genome to restore its viability.

Multiple reactivation is a phenomenon that can be observed in medicine and microbiology. Its essence lies in the formation of a viable virus during re-infection, which avoids direct contact with the infected cell. Against the background of mutations, non-viable viruses can restore their viability, while interacting with other carrier viruses. In this case, the reacting viruses cause complementation and recombination. One of the manifestations of this process is the formation of phage mixtures - derivative individuals that arise during the interaction between viable and non-viable viral particles, as well as with the participation of cellular enzymes. This phenomenon is characterized not only by its complexity and uniqueness, but also by its great practical value, which makes it the object of close attention of scientists around the world.