Schizogony Exoerythrocytic

Schizogony is the process by which a parasite (such as Plasmodium falciparum) reproduces within the host. This process occurs in the liver and includes several stages.

Schizogony in malarial plasmodia begins with the penetration of the parasite into the blood through the skin. The parasite then enters the liver, where it multiplies. In the liver, the parasite produces several thousand merozoites—small cells that invade erythrocytes (red blood cells).

After implantation, merozoites begin to multiply inside red blood cells, forming schizonts - large cells containing many merozoites. Schizonts grow and divide, forming new merozoites, which again invade new red blood cells. This process is repeated many times until the parasite reaches its maximum population.

During the process of schizogony, the parasite can release toxins that can cause various symptoms in the host, such as fever, headache and weakness. Also, in the process of schizogony, parasites can be transmitted from one person to another through the blood.

It is important to note that schizogony is an important stage in the life cycle of Plasmodium falciparum and is necessary for its reproduction and spread. However, if a person is infected with malaria, their body can produce antibodies that block the development of the parasite and prevent it from multiplying inside the body. This treatment is called chemotherapy and can help prevent you from passing malaria to other people.

Exoerythrocyte schizogony (schizogony) - in malar plasmodia, having penetrated the body, it occurs outside of red blood cells (blood cells). Characterized by the development of a large number of merozoids. Appears after 6 hours. The viability of merosides is very low. This is the stage of parasite development when plasmodia are found in the affected liver cells. Method of infection: by the bite of an infected mosquito, which transmits it to an infected person (the definitive host). Malaria is caused by obligate or obligate trematodes. They live in the liver of various animals. The so-called intermediate stage of parasite development plays an important role. When exoerythrocytes there is a parasite (Plasmodium malaria), in the diencephalon, iridociliary ganglia. In this area, under the influence of blood vessels, the processes of necrosis and catalia are formed, which contributes to the capture of macrophages (phagocytes).

In such a place, mature plasmodia are absolutely sensitive to the action of high temperatures and slowly settle on the cell surface. The development of merosites occurs many times faster than in liver tissue. Parasites quickly spread throughout the body using the lymphatic system. Merosides cross the membrane of the nucleus of neighboring cells and penetrate their cytoplasm. The process is chaotic, and the number of merosites can quickly increase into hundreds or thousands. Merosites quite easily penetrate cytoplasmic membranes, then completely destroy the formed elements of the blood. Some of the merosides leave the damaged erythrocyte cell and therefore dissolve, while the remaining ones continue to actively develop. The result is damage to the nucleus of other red blood cells, which forms new merosides. They circulate in the blood for quite a long time. Signs of damage appear after infection. Infected people experience chills. Common symptoms of infection are bleeding gums, signs of jaundice, fever, weakness, headache, etc.