Sizomycin Sulfate

**Sisomycin** is an aminoglycoside antibiotic produced by the bacteria Bacillus brevis or B. globigii.

Synonym: Palomid

When percolated, it has a local anesthetic effect; in large doses or in the form of an aerosol, inhibits the transmission of excitation at neuromuscular synapses of peripheral nerves; improves neuromuscular conduction (after blockade of peripheral nerve trunks) and coordination of movements. Enhances the cardiovascular effects of fentanyl and other narcotic analgesics; reduces