Tersilya syndrome is a clinical pathopsychological complex of secondary mental changes during herpetic infections in persons with affective pathology. The main pathogenetic factor in all cases is intraparenchymal cerebral edema of infectious origin (the most important component of which is exudate, which contains chemicals that are toxic to brain tissue, creating a deficiency of water and substances that promote its resorption). Statistically significantly more often, the syndrome is detected in women as a result of somatic diseases that provoke it (64.7%), alcohol intoxication (11.2%) or organic encephalopathy (24.1%). Tessil syndrome is extremely difficult for patients to tolerate, which is manifested by emotional and behavioral instability, memory loss, anxiety, short temper, insomnia, suicidal thoughts, mood disorders of varying severity, even depression.